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Since there are no known drugs to treat this eye condition, perilla frutescens in an aqueous extract form may result in the relaxation of the ciliary muscle in humans as well.

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This is long, it’s also something that if you read it in a fictional novel, it would be too far fetched to believe.

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Also, excessive pupil dilation may occur as an unwanted side effect.

This dilation may pose a problem since a larger pupil is less efficient at focusing light (see pupil, aperture, and optical aberration for more.) Patients who have accommodative spasm may benefit from being given glasses or contacts that account for the problem or by using vision therapy techniques to regain control of the accommodative system.

This unfortunately makes treatment much more difficult as the side effect of dry eyes and corneal damage can occur.

France, Australia, Canada, and the United Kingdom do have limited availability of BAK free eye drops available in unidose and they must be imported to the United States with a physician's letter to the FDA enclosed with the imported prescription.

A spasm of accommodation (also known as a ciliary spasm, an accommodation, or accommodative spasm) is a condition in which the ciliary muscle of the eye remains in a constant state of contraction.

Normal accommodation allows the eye to "accommodate" for near-vision.

One side effect of cycloplegic drops is that they often have BAK as a preservative ingredient, which with daily use can erode the tear shield, "At each administration of an eye drop containing benzalkonium chloride, its detergent effect disrupts the lipid layer of the tear film.

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